Istanbul’s former bad-lands neighbourhood of Beyoglu is transforming itself into the city’s coolest lifestyle hub.

Istanbul is in the midst of a cultural and architectural revival. This rich and storied city, peppered with Byzantine churches, Ottoman palaces, chaotic bazaars and steamy hammams, has long been the crossroads of East and West, Europe and Asia.

Now, after years of staunch traditionalism and economic depression, Istanbul is reinventing itself as the Mediterranean’s new city of cool. At the heart of this renaissance is Beyoglu. Across the Golden Horn from the old city, the former ramshackle borough of 19th-century apartment blocks and grand Ottoman mansions is rapidly being transformed into a lifestyle hub.

“Ten years ago you wouldn’t walk these streets at night,” says the owner and chef of Mikla, Mehmet Gurs, who led Beyoglu’s transformation when he opened the rooftop club NuTeras in 2001.

The streets surrounding NuTeras are now a hive of construction. The legendary Pera Palace Hotel will reopen next month after a $33 million makeover (it is rumoured Agatha Christie wrote Murder on the Orient Express in room 411). Next door, W Hotels is converting a mansion into a boutique hotel, the group’s second in Istanbul. Around the corner, the ‘starchitect’, Frank Gehry, is drawing up plans for a new cultural centre.

8:30 am
Emerge from the ruffle of feathers that is your bed at Witt Suites, the latest designer digs in the up-and-coming neighbourhood of Cihangir, a grid of steep streets peering over the Bosphorus. The first hotel for the brother-sister team of Secil and Tuncel Erdogan, this 17-room establishment has been fitted by the Turkish design group, Autoban, and is as glamorous as it is functional. Get your heart started with breakfast in the lobby: goodies from Turkey’s plump pantry, including smoked cheese, goat’s feta, sweet vine-ripened tomatoes and pastrami ham with sesame-seed simits.

Witt Suites, 26 Defterdar Yokusu, +90 2122931500, www.wittistanbul.com, Double rooms from €159 ($220), including breakfast.

10:30 am
Spend the morning taking in one or both of Beyoglu’s privately owned museums, both of which gave the area a big cultural injection when they opened in 2004. A few metres off Istiklal Caddesi, the Pera Museum has two floors of permanent exhibition space showing Ottoman-era orientalist paintings and Anatolian weights and ceramics. But it’s the visiting exhibitions that create the most buzz, with works by Fernando Botero, a Colombian figurative artist, exhibiting until mid-July.

Part of an old shipping warehouse on the shores of the Bosphorus, Istanbul Modern is an airy space dedicated to Turkey’s avant-garde artists. The first floor traces Turkish art through the past century, with pieces such as Adnan Coker’s abstract work, Retrospective, and a self-portrait by Sultan Abdul-Mejid II, the last ruler of the Ottoman empire. The bottom floor hosts rotating exhibitions covering a range of disciplines- cinema, photography, sculpture – and the cryptic images of Murat Germen until mid-September.

Pera Museum, 65 Mesrutiyet Caddesi, en.peramuzesi.org.tr, entry 7 lira ($5) a person. Istanbul Modern, Meclis-i Mebusan Caddesi, www.istanbulmodern.org, entry 7 lira, closed Mondays.

1:30 pm
Recharge the batteries at Karakoy Lokantasi, an airy diner around the corner from Istanbul Modern. Also designed by Autoban, the two-storey venue has aqua-blue walls, chequered floors and a wrought-iron staircase running up its belly, with a fabulous array of Turkish treats on the menu, such as spicy white beans cooked in an earthen pot and mash of creamy eggplant with barbecued lamb. For dessert, slip next door to Karakoy Gulluoglu, an old-fashioned baklava shop that locals claim rivals that from Gaziantep, the home of the sticky nut-filled pastry.

Karakoy Lokantasi, Kemankes Caddesi, phone +90 2122924455, lunch for two, 40 lira. Karakoy Gulluoglu, Mumhane Caddesi, +90 2122930910, www.karakoygulluoglu.com, dessert for two, 6 lira.

3 pm
Continue along the coastline to the Galata Bridge, taking in views of Sultanahmet and the bustling Golden Horn until you reach the funicular railway, the cheat’s express to reach the top of Beyoglu’s hillside. Safely at the top you can now skip down to the iconic Galata Tower, which was built in 1348 by the Genoese as part of the fortification of their semi-independent city state here. It once served as a jail and fire tower. Take the elevator to the top for 360-degree views of the city and then back down for a cup of Turkish tea and, for those inclined, a narghile (water pipe with fruit-flavoured tobacco) at Ceneviz Cafe.

Galata Tower, www.galatatower.net, entry 10 lira. Ceneviz Cafe, Fircasi Sokak, +90 5365804300

4:30 pm
The neighbourhood of Galata is the hot spot for shopping. Try Laundromat (Galip Dede Caddesi, www.laundromat-ist.com) for stunning women’s threads by bohemian Turkish designers such as Nihan Peker and Gunes Dericioglu, or nearby Adem & Havva (3 Cemekan Sokak, +90 2122450551) for handmade leather sandals and vintage clothes. For more home-grown Turkish delights, return to Cihangir. Parisian-style Mariposa (11A Simsirci Sokak, +90 2122490483) sells lovely tailor-made vintage dresses in flower and chequered patterns (pick a dress from the rack and they will remake it in your size in two to three days). Or try Zihni Sinir (13 Agahamami Sokak, www.zihnisinir.com) for handmade toys and clocks.

7:30 pm
Mikla, on the top floor of the Marmara Pera Hotel, has some of the best views in Istanbul. If you aim to get here about dusk, arm yourself with a glass of punchy Turkish wine and watch the sun sink dramatically over the higgledy-piggledy rooftops of this ancient and chaotic city. The Finnish-Turkish owner and chef of Mikla, Mehmet Gurs, is in the vanguard of the slow food and organic movements in Istanbul. Scouring the countryside, Gurs has unearthed a pantry of little-known ingredients such as lavender-infused honey, a centuries-old style of halva and miniature olives to incorporate into his menu. They are best sampled in the extravagant nine-course degustation meal with dishes such as cherry wood-smoked lamb, Black Sea hamsi sardines quickly fried between paper-thin slices of bread, and quince and pear terrine, all paired with superb Turkish wines.

Mikla, +90 2122935656, www.istanbulyi.com, nine-course degustation menu for two, 110 lira; with matching Turkish wines, 190 lira.

11 pm
Pera is the heart of Beyoglu’s bar scene and you’ll find a raft of lively watering holes in the narrow streets around the Marmara Pera Hotel. For cocktails with local celebs and the jet-setter crowd, head to alfresco NuTeras (147 Mesrutiyet Caddesi), which recently reopened after a facelift and change of ownership. Or for a grungier atmosphere, head for Tunel and bars such as Otto (8 Sehbender Sokak, www.otto-restaurant.com), to find a prime perch on the street for people-watching.

This article appeared in a May 2010 issue of the Sydney Morning Herald and Age newspapers Traveller.